A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization
نویسندگان
چکیده
منابع مشابه
Immortalization of Syrian Hamster Embryo Cells Is in Itself a Multistep Event1
The hypothesis that induction of immortalization of rodent cells follows one-hit kinetics was tested by the determination of frequencies of immor talization of Syrian hamster embryo cells after treatment with benzo(a)pyrene, \-rays, or ethylnitrosourea. Contrary to expectation, immortalization did not occur in a single step. Full immortalization appeared to be a process which required at least ...
متن کاملImmortalization of Syrian hamster embryo cells is in itself a multistep event.
The hypothesis that induction of immortalization of rodent cells follows one-hit kinetics was tested by the determination of frequencies of immortalization of Syrian hamster embryo cells after treatment with benzo(a)pyrene, X-rays, or ethylnitrosourea. Contrary to expectation, immortalization did not occur in a single step. Full immortalization appeared to be a process which required at least t...
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The ovarian reserve (OR) gradually decreases throughout the female fertile life. This continuous depletion in OR is irreversible. This occurs through a programmed cell death known apoptosis. Some factors hasten such depletion such as chemo- and radiotherapy. Others have been investigated in trials to preserve the OR including gonadotropins, cytokines, growth hormones, nitric oxide and reorganiz...
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A 2-year-old male hamster was presented because of left facial swelling and salivation. Necropsy wasperformed and affected cheek pouch with tissue samples of regional and internal organs were submitted forhistopathological study. In histopathological examination it was found that the tumor consisted of cords andislands of tumoric epithelial cells which were diffused in the dermis. Vacoulation o...
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ژورنال
عنوان ژورنال: Oncogene
سال: 1998
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1202261